Method
1. Cook the Pasta
Bring a large pot of heavily salted water to a boil and cook the penne until just al dente, according to package directions. Reserve ½ cup pasta water, then drain.
2. Sear the Chicken
Heat the olive oil in a large sauté pan over medium heat. Season the chicken on both sides with oregano, garlic powder, paprika, salt, and pepper. Sear until deeply golden on each side and cooked through, 4-6 minutes per side. Transfer to a plate to rest.
3. Build the Roux
Melt the butter in the same pan over medium-low heat. Add the garlic, oregano, and a pinch each of salt and pepper, and cook, stirring frequently, for 1 minute until fragrant. Stir in the flour and cook for another minute, stirring constantly.
4. Deglaze and Simmer
Pour in the white wine, scraping up any browned bits from the bottom of the pan, and let it bubble for 1 minute. Whisk in the heavy cream and simmer over medium-low heat, stirring occasionally, until smooth and slightly thickened, a few minutes.
5. Finish the Sauce
Stir in the Parmesan until melted and the sauce reaches a glossy, coating consistency. Season to taste with salt and pepper.
6. Combine and Serve
Slice the rested chicken into strips. Add the pasta to the sauce and toss to coat, thinning with a splash of reserved pasta water as needed. Fold in the chicken and toss until everything is warmed through. Garnish with extra Parmesan and parsley.